I haven't seen it done yet, and this seems to be the place where it should be done.
I challenge all of you to make a Binding of Isaac clone using Zelda graphics and items.
GB Zelda is probably the best graphical source since it has tons and tons of items. Seriously though; think about it- Rings instead of trinkets, use items are Zelda items, and bosses can be from the range of bosses in the zelda series. It just works.
If someone makes this I dunno maybe I'll send you some Xbox One launch party/Capcom swag (you know; Resident Evil soundtrack, Dead Rising 3 stuff, a weeaboo pin set, etc etc)
All of the resources are completely readily available too.