If you like Calvin and Hobbes, check out Ozy and Millie. It's a webcomic so it never got syndicated, but when I read through the archives it felt like I was reading C&H much of the time. It's ten years old, and he's just now ending the comic (ironic considering that C&H also ended after 10 years) but it's definitely worth a read.
Pearls is pretty funny, but tends to get rather repetitive after a while.