Book: 1984 by George Orwell
Game: Bioshock
Movie: The Dark Knight
Song: Pyramid Song by Radiohead
I highly recommend all of these to anyone. 1984 is the greatest book I've ever read, and has had a profound effect on the way I think. Bioshock is a fantastic game, although close seconds would be Metal Gear Solid 3 and the masterpiece that is Shadows of the Colossus. The Dark Knight is an excellent movie featuring the best performance this side of Daniel Plainview: Heath Ledger as the Joker. The themes were great and pertinent, helping to bring this movie above my other favorite: Sean of the Dead. Pyramid Song is a masterpiece, like many of Radiohead's songs. Time and again they've changed the way we look at music and have significantly influenced modern music. I would recommend all of their music, every single song (since their inaugural cd, Pablo Honey, that is).